Science

LEVERAGING THE LATEST ADVANCES IN NEUROSCIENCE

Age-related cognitive decline is the natural deterioration in our cognitive capabilities as we age. At a molecular level, this decline starts in our early 20s, with the physiological effects beginning to manifest themselves in our 40s. During this gradual decline we begin to feel as if we are no longer performing at peak mental capacity and the demands of everyday life become increasingly difficult to manage. Each one of us will experience this progressive decline in cognitive function, making maintaining a healthy brain and lifestyle a top priority for adults at all ages.

UNDERSTANDING THE AGING BRAIN

Recent breakthroughs in our understanding of how the brain ages present the exciting possibility that the natural decline in cognitive performance may be a reversible process.

Our founder and CEO Dr. Shawn Watson's seven years of research and series of publications in top academic journals explored this exciting possibility, culminating in a new understanding of how our brain's age. These findings have since been corroborated in neuroscience laboratories around the world. With this knowledge in hand, Senescence Life Sciences has developed and patented a systematic strategy designed to combat the underlying mechanisms responsible for age-related cognitive decline.

OUR BRAIN HEALTH STRATEGY

All of our products are designed as a holistic strategy to combat brain aging. Our research, in combination with leading laboratories around the world, has identified three primary processes responsible for disrupting the ability of aging brain cells to communicate effectively with one-another. There is now clear empirical evidence to support the premise that interventions at these key targets carry substantial benefits for the brain.

Our brain cells require large amounts of oxygen to support their metabolic needs. Comparatively, our brain makes up only 2% of our total body mass but utilizes 20% of our body’s oxygen. Being exposed to high levels of oxygen makes our brain cells (neurons) vulnerable to free radical attack, a process known as oxidation. Lipids (fats) are particularly susceptible to oxidation due to their chemical structure and sheer abundance in the brain, as 60% of our brain is fat. Certain types of fats, such as polyunsaturated fatty acids, are arguably the first and most important site of oxidation within the brain. Once oxidized, these compounds can cause significant changes in neuronal (electro)physiology and impair the ability of our neurons to properly communicate with one another.

Our products contain brain-targeted antioxidants that decrease the overall oxidation rates of polyunsaturated fatty acids. In addition to sacrificial anti-oxidants (those that are used and then expelled from the body), our products are designed to gradually increase de novo (natural production) of internal anti-oxidants within neurons. While taking time to build-up, this strategy helps to rebuild a neuron’s natural lipid-based anti-oxidant defense system. Reducing lipid oxidation has been linked to substantial increases in neuronal performance and prevents many aspects of age-related changes in brain function.

Oxidation is a force that will work against the brain throughout its lifetime. Our neurons have a host of enzymes and compounds that are used both as a first line of defence against initial oxidative attacks and as a means to repair cellular components that have already been damaged. However, as we age these repair mechanisms begin to slow down and lose their effectiveness – resulting in increased damage and a build-up of toxic compounds within our brains. These toxins have been linked to various brain health-related conditions, including neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease.

Our products are formulated to combat oxidation and support the natural repair mechanisms that are already working within our brains. Our patent pending formulas up-regulate intrinsic enzymatic repair mechanisms, such as glutathione peroxidase, as well as increase antioxidant levels via de novo (natural production) of internal antioxidants, such as glutathione (GSH). By supporting these mechanisms we help to correct and shift the balance, so that repair mechanisms once again outweigh damaging events.

There is mounting evidence that the gradual increase in inflammation within the aging brain is a key factor in a number of age-related changes in brain performance. When inflammation occurs within a healthy brain, compounds are released that bind to specific receptors on neurons and trigger a host of cognitive changes, including altered cognitive performance, impaired learning and memory, and changed emotional states. If left unchecked or if the body is unable to bring levels back to baseline, these inflammatory molecules can begin to cause irreversible damage and potentially even lead to neuronal death. This is seen in neuro-degenerative conditions such as Alzheimer’s disease.

Our patent pending formulas use both renewable and sacrificial compounds to disengage and remove inflammatory lipid-based metabolites which have built up within the brain and within individual neurons. In addition, our strategy provides some of the key substrates (raw materials) necessary to export these toxic inflammatory metabolites out of the brain and allow it once again to operate at peak efficiency.

 

Our Pharmaceutical Candidates and Pipeline

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